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Sunday, July 8th, 2018

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Image courtesy Flow Fire Games

Back in 1982, Larry DeMar and Eugene Jarvis made a game called Manchester Great Sale Sale Online View Classic ankle boots burdeos HvbAcW
, a coin-op arcade game where the player zaps endless waves of machines bent on the annihilation of mankind. I bring this up because Synthetik , recently released by Flow Fire Games , feels like the spiritual successor to Robotron as a top-down action roguelike. On the surface, you’ll spend much of your time blasting, and being blasted by, many many robots. But under the simple running and gunning are layers of weapons, power-ups, difficulty adjustments, and a fine sheen of polish.

Image courtesy Flow Fire Games

Synthetik revolves around you, an android programmed with human consciousness. You willbe duking it out against legions of robots to get to the top of the Kaida Corporation and stop the activation of the Heart of Armageddon , and thus, the destruction of humanity. If you’d prefer, you face the robots hordes with a friend in co-op mode. But l ike so many roguelikes before it, Synthetik gives you one life and you’ll more than likely lose it with the amount of enemies and ordinance thrown your way.

And yet , I would say Synthetik is also one of the more accessible and player friendly roguelikes out there. Because while the overall challenge is rather high, Synthetik allows players to pick and choose a series of curses modifiers to make the next playthrough more or less difficult. For example, you can forgo Synthetik’s active reload system(ejecting spent magazines and reloading), and turn down the base difficulty. Or you can make your robot opponents stronger, faster, hit harder, and put penalties on your own firearms and movement. More curses translate to rarer weapons but with potent power-ups to compensate, along with more experience for permanent upgrades to your android’s class type. It’s a very welcome addition to a genre where the word challenging is often confused for punishing .

Image courtesy Flow Fire Games

Combat is a combination of shooting and movement, and weapons in Synthetik come in a variety of pistols, shotguns, machine guns, rocket, and grenade launchers to start. Aiming is a big part of combat, as the circle around your target reticle expands when you move, or fire wildly, reducing your accuracy. Standing still for those precious few seconds and letting off a few measured bursts of fire means more accurate shots and the possibility of a critical hit.

Glossary

Study record managers: refer to the Data Element Definitions if submitting registration or results information.

A type of eligibility criteria that indicates whether people who do not have the condition/disease being studied can participate in that clinical study.
An arm type in which a group of participants receives an intervention/treatment considered to be effective (or active) by health care providers.
An unfavorable change in the health of a participant, including abnormal laboratory findings, that happens during a clinical study or within a certain amount of time after the study has ended. This change may or may not be caused by the intervention/treatment being studied.
A type of eligibility criteria that indicates the age a person must be to participate in a clinical study. This may be indicated by a specific age or the following age groups:

The age groups are:

A method used to assign participants to an arm of a clinical study. The types of allocation are randomized allocation and nonrandomized.
A group or subgroup of participants in a clinical trial that receives a specific intervention/treatment , or no intervention, according to the trial's protocol .
A general description of the clinical trial arm. It identifies the role of the intervention that participants receive. Types of arms include experimental arm , active comparator arm , placebo comparator arm , sham comparator arm , and no intervention arm .
Data collected at the beginning of a clinical study for all participants and for each arm or comparison group. These data include demographics, such as age, sex/gender, race and ethnicity, and study-specific measures (for example, systolic blood pressure, prior antidepressant treatment).
Indicates that the study sponsor or investigator recalled a submission of study results before quality control (QC) review took place. If the submission was canceled on or after May 8, 2018, the date is shown. After submission of study results, a study record cannot be modified until QC review is completed, unless the submission is canceled.
Information required by the Food and Drug Administration Amendments Act of 2007 . In general, this is a description of any agreement between the sponsor of a clinical study and the principal investigator (PI) that does not allow the PI to discuss the results of the study or publish the study results in a scientific or academic journal after the study is completed.
A sponsor or investigator may submit a certification to delay submission of results information if they are applying for FDA approval of a new drug or device, or new use of an already approved drug or device. A sponsor or investigator who submits a certification can delay results submission up to 2 years after the certification/extension first submitted date, unless certain events occur sooner. See sequin embellished sandals Official Site Cheap Online Free Shipping Visa Payment Buy Cheap Authentic UTDlnGVL
in the Results Data Element definitions for more information about this certification.
The date on which information about a certification to delay submission of results or an extension request was first available on ClinicalTrials.gov. ClinicalTrials.gov does not indicate whether the submission was a certification or extension request. There is typically a delay between the date the study sponsor or investigator submitted the certification or extension request and the first posted date .
The date on which the study sponsor or investigator first submitted a certification or an extension request to delay submission of results. A sponsor or investigator who submits a certification can delay results submission up to 2 years after this date, unless certain events occur sooner. There is typically a delay between the date the certification or extension request was submitted and the date the information is first available on ClinicalTrials.gov ( certification/extension first posted ).
The date on which the study sponsor or investigator first submitted a certification or an extension request that is consistent with National Library of Medicine (NLM) quality control (QC) review criteria. The sponsor or investigator may need to revise and submit a certification or extension request one or more times before NLM's QC review criteria are met. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria. Meeting QC criteria for an extension request does not mean that the National Institutes of Health (NIH) has determined that the request demonstrates good cause. The process for review and granting of extension requests by the NIH is being developed.
In the search feature, the City field is used to find clinical studies with locations in a specific city. The Distance field is used to find studies with locations within the specified distance from a city in number of miles. For example, if you choose Illinois as the state , identifying "Chicago" as the city and "100 miles" as the distance will find all studies listing a location within 100 miles of Chicago.
A research study involving human volunteers (also called participants) that is intended to add to medical knowledge. There are two types of clinical studies: interventional studies (also called clinical trials) and observational studies .
Another name for an interventional study .
The unique identification code given to each clinical study upon registration at ClinicalTrials.gov. The format is "NCT" followed by an 8-digit number (for example, NCT00000419).
An organization other than the sponsor that provides support for a clinical study. This support may include activities related to funding, design, implementation, data analysis, or reporting.
The disease, disorder, syndrome, illness, or injury that is being studied. On ClinicalTrials.gov, conditions may also include other health-related issues, such as lifespan, quality of life, and health risks.
The name and contact information for the person who can answer enrollment questions for a clinical study. Each location where the study is being conducted may also have a specific contact, who may be better able to answer those questions.
In the search feature, the Country field is used to find clinical studies with locations in a specific country. For example, if you choose the United States, you can then narrow your search by selecting a state and identifying a city and distance .
A type of intervention model describing a clinical trial in which groups of participants receive two or more interventions in a specific order. For example, two-by-two cross-over assignment involves two groups of participants. One group receives drug A during the initial phase of the trial, followed by drug B during a later phase. The other group receives drug B during the initial phase, followed by drug A. So during the trial, participants "cross over" to the other drug. All participants receive drug A and drug B at some point during the trial but in a different order, depending on the group to which they are assigned.
A group of independent scientists who monitor the safety and scientific integrity of a clinical trial . The DMC can recommend to the sponsor that the trial be stopped if it is not effective, is harming participants, or is unlikely to serve its scientific purpose. Members are chosen based on the scientific skills and knowledge needed to monitor the particular trial. Also called a data safety and monitoring board, or DSMB.
A phase of research used to describe exploratory trials conducted before traditional phase 1 trials to investigate how or whether a drug affects the body. They involve very limited human exposure to the drug and have no therapeutic or diagnostic goals (for example, screening studies, microdose studies).
The key requirements that people who want to participate in a clinical study must meet or the characteristics they must have. Eligibility criteria consist of both inclusion criteria (which are required for a person to participate in the study) and exclusion criteria (which prevent a person from participating). Types of eligibility criteria include whether a study accepts healthy volunteers , has age or age group requirements, or is limited by sex .
The number of participants in a clinical study. The "estimated" enrollment is the target number of participants that the researchers need for the study.
A type of eligibility criteria . These are reasons that a person is not allowed to participate in a clinical study.
A way for patients with serious diseases or conditions who cannot participate in a clinical trial to gain access to a medical product that has not been approved by the U.S. Food and Drug Administration (FDA) . Also called compassionate use. There are different expanded access types .

For more information, see FDA Expanded Access: Information for Patients .

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Above: CogniToys is starting a new crowdfunding campaign.

Image Credit: Cognitoys

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The original CogniToys tapped IBM Watson for its AI smarts. But in the past year, Elemental Path replaced Watson with its own Friendgine AI technology,a cloud-based artificial intelligencesoftware platform that allows smart toys to hold an intelligent conversation with a child.

The friendly green STEMosaur is designed as a learning companion and is customizable for various lessons in science, technology, engineering, and math (STEM). It also offers lessons in coding.

Elemental Path hopes to raise $25,000 in 45 days, with an early bird backing level starting at $99.

“We launched the Dino in 2015 with a very successful crowdfunding campaign that raised over aquarter-million dollars. In the past two years since, we’ve definitely learned a lot about our users andwhat they want in a product, and we are using these important lessons to create an even better andmore hands-on experience with kids,” said Donald Coolidge, CEO and cofounder of Elemental Path, in a statement.“This time around with the STEMosaur, we’ll be offering a more interactive and engaging experience — where kids will have the ability to construct the STEMosaur from scratch, carry intelligent conversation,play games, and also learn the basics of coding.”

Above: CogniToys first debuted in 2015. Now STEMosaur is joining the family.

With STEMosaur, kids ages seven and older will be able to construct, code, and play. The learning begins with ahands-on exercise that allows children to construct their new friend from a variety of building pieces tobring it to life.

Once you build it, the Wi-Fi-enabled STEMosaur will be able to use Elemental Path’s Friendgine to hold a conversation, tell jokes, and play games that engage the user’s imagination and creativity.

Above: CogniToys’ STEMosaur can help kids learn to code.

Each and every app in the list is excellent in its own way. Taken together, our collection is like a snapshot of the best of the Google Play store at the time of writing. If we missed something, or you have a recommendation, be sure to drop us a line in the comment section below. We keep this list current, so your suggestions may make it into the next update .

Best Android Browser Apps

Free A clean, tabbed browser, Dolphin delivers an excellent user experience on Android, almost making you forget that you're on a mobile device. Dolphin also supports tight integration with services like Evernote and LastPass, as well as robust settings. Our favorite feature is gestures, which might not always be efficient but are definitely cool to use. Dolphin also has integrated ad-blocking and support for Flash. Yes, Flash!

Free What's incredible about the Android version of Firefox is that it feels just as mature, if not more so, than the desktop version. It's also lickety-split fast and has a clean design that is a joy on mobile. However, once some of the Christian Louboutin PointedToe Platform Pumps Cheap Sale Great Deals IvLHoJz7F
makes its way over, it should be even more impressive. Mozilla also makes a big point about how it doesn't collect your data, and we are pleased to see that the app comes with a full complement of security settings—including an option to protect your information from advertisers and a private browsing mode. Like the desktop version, Firefox for mobile has a robust selection of plug-ins, excellent tab management, and a dynamic start page for bookmarks and the latest headlines.

Free Firefox Focus doesn't track your browsing and deletes your history when you leave the app. It even strips away all the ads and trackers on a site, so pages load very quickly and you can often get around most paywalls and article limits. The minimalist landing page and bright color scheme also make it enjoyable to use. Do yourself a favor and set it as your default if you care about your privacy.

Free Although it's not as popular as Chrome and Firefox, Opera is just as capable a browser on Android. With a slick design, it aims to be your gateway to web content with features like a built-in news portal and the Opera mobile apps store. Opera also takes it easy on your data plan with special compression tools and ad-blocking software. If you want to keep your browsing discreet, Opera offers a private browsing mode.

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Free Cookpad connects you with a vibrant array of recipes. Easily add favorite recipes, manage shopping lists, and find new recipes you'll love based on those you already like. Once you start using it, you'll have one less excuse to eat out.

Free Remember the bad old days of ordering food? You needed takeout menus, knowledge of the terrain ("will they even deliver out here?"), cash, and faith that the person jotting down your order got it right. Seamless takes care of all that, even letting you pay via credit card from your Android. The only drawback? It's not available in every city (or even every state), though it has expanded its range dramatically since it was first included on this list.

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